The principles of SFC are similar to those of liquid chromatography, however SFC typically uses carbon dioxide as the main mobile phase. SFC is essentially a normal-phase chromatographic technique with inherent high speed and efficiency due to its mobile phase. As a high pressure liquid, or supercritic4al fluid, using CO2 is a smart solvent for its low viscosity and high diffusivity needed in today’s demanding purification labs and also a sustainable solvent as it is reused after being discarded from other industrial processes.
SFC excels at separating and purifying chiral compounds and natural products because it’s faster, uses much less solvent, and overall is a less expensive and greener method that exceeds high pressure liquid chromatography (HPLC) in performance for chiral separations.
Whether you’re just looking to analyze chiral compounds or need to purify those compounds, Waters has the solution that fits your needs. More about Waters SFC systems here
